Computer-aided Drug Design Applied to Parkinson Targets.

ABSTRACT: BACKGROUND:Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by debilitating motor deficits, as well as autonomic problems, cognitive declines, changes in affect and sleep disturbances. Although the scientific community has performed great efforts in the study of PD, and from the most diverse points of view, the disease remains incurable. The exact mechanism underlying its progression is unclear, but oxidative stress, mitochondrial dysfunction and inflammation are thought to play major roles in the etiology. OBJECTIVE:Current pharmacological therapies for the treatment of Parkinson's disease are mostly inadequate, and new therapeutic agents are much needed. METHODS:In this review, recent advances in computer-aided drug design for the rational design of new

SUBMITTER: Ishiki HM 

PROVIDER: S-EPMC6080092 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature