The Many Faces of Long Noncoding RNAs in Cancer.

ABSTRACT:

Significance

The emerging connections between an increasing number of long noncoding RNAs (lncRNAs) and oncogenic hallmarks provide a new twist to tumor complexity. Recent Advances: In the present review, we highlight specific lncRNAs that have been studied in relation to tumorigenesis, either as participants in the neoplastic process or as markers of pathway activity or drug response. These transcripts are typically deregulated by oncogenic or tumor-suppressing signals or respond to microenvironmental conditions such as hypoxia.

Critical issues

Among these transcripts are lncRNAs sufficiently divergent between mouse and human genomes that may contribute to biological differences between species.

Future directions

From a translational standpoint, knowledge about prima

SUBMITTER: Wu X 

PROVIDER: S-EPMC6080117 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature