A step closer in defining glycosylphosphatidylinositol anchored proteins role in health and glycosylation disorders.

ABSTRACT: Glycosylphosphatidylinositol anchored proteins (GPI-APs) represent a class of soluble proteins attached to the external leaflet of the plasma membrane by a post-translation modification, the GPI anchor. The 28 genes currently involved in the synthesis and remodelling of the GPI anchor add to the ever-growing class of congenital glycosylation disorders. Recent advances in next generation sequencing technology have led to the discovery of Mabry disease and CHIME syndrome genetic aetiology. Moreover, with each described mutation known phenotypes expand and new ones emerge without clear genotype-phenotype correlation. A protein database search was made for human GPI-APs with defined pathology to help building-up a physio-pathological mechanism from a clinical perspective. GPI-APs function in v

SUBMITTER: Manea E 

PROVIDER: S-EPMC6080220 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature