New Insights Into Permeation of Large Cations Through ATP-Gated P2X Receptors.

ABSTRACT: The permeability of large cations through the P2X pore has remained arguably the most controversial and complicated topic in P2X-related research, with the emergence of conflicting studies on the existence, mechanism and physiological relevance of a so-called "dilated" state. Due to the important role of several "dilating" P2X subtypes in numerous diseases, a clear and detailed understanding of this phenomenon represents a research priority. Recent advances, however, have challenged the existence of a progressive, ATP-induced pore dilation, by demonstrating that this phenomenon is an artifact of the method employed. Here, we discuss briefly the history of this controversial and enigmatic dilated state, from its initial discovery to its recent reconsideration. We will discuss the literature

SUBMITTER: Peverini L 

PROVIDER: S-EPMC6080412 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature