Genetic diversity of merozoite surface protein-1 C-terminal 42 kDa of Plasmodium falciparum (PfMSP-1₄₂) may be greater than previously known in global isolates.

ABSTRACT:

Background

The C-terminal 42 kDa region of merozoite surface protein-1 of Plasmodium falciparum (PfMSP-1₄₂) is the target of an immune response. It has been recognised as one of the promising candidate antigens for a blood-stage malaria vaccine. Genetic structure of PfMSP-1₄₂ has been considered to be largely conserved in the P. falciparum population. However, only limited information is currently available. This study aimed to analyse genetic diversity and the effect of natural selection on PfMSP-1₄₂ among the Myanmar P. falciparum population and compare them with publicly available PfMSP-1₄₂ from global P. falciparum populations.

Methods

A total of 69 P. falciparum clinical isolates collected from Myanmar malaria patients in Uppe

SUBMITTER: Thai TL 

PROVIDER: S-EPMC6080494 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature