Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis.

ABSTRACT: During growth, homeostasis and regeneration, stem cells are exposed to different energy demands. Here, we characterise the metabolic pathways that mediate the commitment and differentiation of mouse skeletal muscle stem cells, and how their modulation can influence the cell state. We show that quiescent satellite stem cells have low energetic demands and perturbed oxidative phosphorylation during ageing, which is also the case for cells from post-mortem tissues. We show also that myogenic fetal cells have distinct metabolic requirements compared to those proliferating during regeneration, with the former displaying a low respiration demand relying mostly on glycolysis. Furthermore, we show distinct requirements for peroxisomal and mitochondrial fatty acid oxidation (FAO) in myogenic cells.

SUBMITTER: Pala F 

PROVIDER: S-EPMC6080609 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature