Comparison of three commercial knowledge bases for detection of drug-drug interactions in clinical decision support.

ABSTRACT:

Objective

To compare 3 commercial knowledge bases (KBs) used for detection and avoidance of potential drug-drug interactions (DDIs) in clinical practice.

Methods

Drugs in the DDI tables from First DataBank (FDB), Micromedex, and Multum were mapped to RxNorm. The KBs were compared at the clinical drug, ingredient, and DDI rule levels. The KBs were evaluated against a reference list of highly significant DDIs from the Office of the National Coordinator for Health Information Technology (ONC). The KBs and the ONC list were applied to a prescription data set to simulate their use in clinical decision support.

Results

The KBs contained 1.6 million (FDB), 4.5 million (Micromedex), and 4.8 million (Multum) clinical drug pairs. Altogether, there were 8.6 million unique pairs,

SUBMITTER: Fung KW 

PROVIDER: S-EPMC6080681 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature