TMEM17 promotes malignant progression of breast cancer via AKT/GSK3β signaling.

ABSTRACT:

Purpose

Current knowledge of TMEM17, a recently identified protein of the transmembrane (TMEM) family, is limited, especially with respect to its expression and biological functions in malignant tumors. This study analyzed TMEM17 expression in invasive breast cancer tissue and breast cell lines and its relevance to clinicopathological factors, and investigated the mechanisms underlying the biological effects of TMEM17 on breast cancer cells.

Patients and methods

TMEM17 protein expression was determined in 20 freshly harvested specimens (tumor and paired normal tissues) by Western blotting. Immunohistochemical analysis was performed to determine the expression and subcellular localization of TMEM17 in samples from 167 patients (mean age, 49 years) diagnosed with invasive duct

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC6080873 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature