HLA-DQβ1 amino acid position 87 and DQB1*0301 are associated with Chinese Han SLE.

ABSTRACT:

Background

Several susceptibility loci have been identified associated with Chinese Han systemic lupus erythematosus (SLE).

Methods

We carried out imputation of classical HLA alleles, amino acids and Single Nucleotide Polymorphisms (SNPs) across the MHC region in Chinese Han SLE genome-wide association study (GWAS) of mainland and Hong Kong populations for the first time using newly constructed Han-MHC reference panel followed by stepwise conditional analysis.

Results

We mapped the most significant independent association to HLA-DQβ1 at amino acid position (Phe87, p = 7.807 × 10^-17 ) and an independent association at HLA-DQB1*0301 (P_condiational  = 1.43 × 10^-7 ).

Conclusion

Our study illustrates the value of population-specific

SUBMITTER: Sun J 

PROVIDER: S-EPMC6081216 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature