CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses.

ABSTRACT: Ca²⁺ release-activated Ca²⁺ channel regulator 2A (CRACR2A) is expressed abundantly in T cells and acts as a signal transmitter between TCR stimulation and activation of the Ca²⁺/NFAT and JNK/AP1 pathways. CRACR2A has been linked to human diseases in numerous genome-wide association studies and was shown to be one of the most sensitive targets of the widely used statin drugs. However, the physiological role of CRACR2A in T cell functions remains unknown. In this study, using transgenic mice for tissue-specific deletion, we show that CRACR2A promotes Th1 responses and effector function of Th17 cells. CRACR2A was abundantly expressed in Th1 and Th17 cells. In vitro, deficiency of CRACR2A decreased Th1 differentiation under nonpolarizing conditions, whereas the

SUBMITTER: Woo JS 

PROVIDER: S-EPMC6081249 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature