Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis.

ABSTRACT: Our recent genome-wide association study found that the NELFCD/CTSZ locus was significantly associated with progression of primary biliary cholangitis (PBC) to jaundice stage in the Japanese population. In this study, we investigated the role of cathepsin Z in the etiology and pathology of PBC. Serum cathepsin Z levels were measured using enzyme-linked immunosorbent assay. The expression and localization of cathepsin Z in liver specimens were analyzed by western blotting and immunohistochemistry. In PBC patients, serum cathepsin Z levels were significantly increased with disease progression. In addition, its levels were positively correlated with alanine transaminase, aspartate transaminase and total bilirubin, and were negatively correlated with platelet count and albumin. Cathepsin Z exp

SUBMITTER: Aiba Y 

PROVIDER: S-EPMC6081405 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature