Genetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations.

ABSTRACT: Previous genome-wide association studies (GWAS) suggest that rs10489202 in the intron of MPC2 (mitochondrial pyruvate carrier 2) is a risk locus for schizophrenia in Han Chinese populations. To validate this discovery, we conducted a replication analysis in an independent case-control sample of Han Chinese ancestry (437 cases and 2031 controls), followed by a meta-analytic investigation in multiple East Asian samples. In the replication analysis, rs10489202 showed marginal association with schizophrenia (two-tailed P = 0.071, OR = 1.192 for T allele); in the meta-analysis using a total of 14,340 cases and 20,349 controls from ten East Asian samples, rs10489202 was genome-wide significantly associated with schizophrenia (two-tailed P = 3.39 × 10^-10, OR = 1.161 for T allele, under

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6081446 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature