Antiviral and Antioxidant Activity of a Hydroalcoholic Extract from Humulus lupulus L.

ABSTRACT: A hydroalcoholic extract from female inflorescences of Humulus lupulus L. (HOP extract) was evaluated for its anti-influenza activity. The ability of the extract to interfere with different phases of viral replication was assessed, as well as its effect on the intracellular redox state, being unbalanced versus the oxidative state in infected cells. The radical scavenging power, inhibition of lipoperoxidation, and ferric reducing activity were assayed as antioxidant mechanisms. A phytochemical characterization of the extract was also performed. We found that HOP extract significantly inhibited replication of various viral strains, at different time from infection. Viral replication was partly inhibited when virus was incubated with extract before infection, suggesting a direct effect

SUBMITTER: Di Sotto A 

PROVIDER: S-EPMC6081516 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature