Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport.

ABSTRACT:

Introduction

The mammalian SPS1-related proline/alanine-rich serine-threonine kinase SPAK (STK39) modulates ion transport across and between epithelial cells in response to environmental stimuli such osmotic stress and inflammation. Research over the last decade has established a central role for SPAK in the regulation of ion and water transport in the distal nephron, colonic crypts, and pancreatic ducts, and has implicated deregulated SPAK signaling in NaCl-sensitive hypertension, ulcerative colitis and Crohn's disease, and cystic fibrosis. Areas covered: We review recent advances in our understanding of the role of SPAK kinase in the regulation of epithelial transport. We highlight how SPAK signaling - including its upstream Cl^- sensitive activators, the WNK kinases, a

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6081737 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature