Imaging Neurotensin Receptor in Prostate Cancer With ⁶⁴Cu-Labeled Neurotensin Analogs.

ABSTRACT:

Introduction

Neurotensin receptor 1 (NTR-1) is expressed and activated in prostate cancer cells. In this study, we explore the NTR expression in normal mouse tissues and study the positron emission tomography (PET) imaging of NTR in prostate cancer models.

Materials and methods

Three ⁶⁴Cu chelators (1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid [DOTA], 1,4,7-triazacyclononane-N,N',N″-triacetic acid [NOTA], or AmBaSar) were conjugated to an NT analog. Neurotensin receptor binding affinity was evaluated using cell binding assay. The imaging profile of radiolabeled probes was compared in well-established NTR⁺ HT-29 tumor model. Stability of the probes was tested. The selected agents were further evaluated in human prostate cancer PC3 xenog

SUBMITTER: Deng H 

PROVIDER: S-EPMC6081756 | biostudies-literature | 2017 Jan-Dec

REPOSITORIES: biostudies-literature