Cerebrospinal fluid GAP-43 in early multiple sclerosis.

ABSTRACT:

Background/objective

Novel biomarkers identifying and predicting disease activity in multiple sclerosis (MS) would be valuable for primary diagnosis and as outcome measures for monitoring therapeutic effects in clinical trials. Axonal loss is present from the earliest stages of MS and correlates with disability measures. Growth-associated protein 43 (GAP-43) is a presynaptic protein with induced expression during axonal growth. We hypothesized this protein could serve as a biomarker of axonal regeneration capacity in MS.

Methods

We developed a novel GAP-43 enzyme-linked immunosorbent assay for quantification in cerebrospinal fluid (CSF) and measured GAP-43 levels in 71 patients with clinically isolated syndrome, 139 MS patients and 51 controls.

Results

GAP-43 concentr

SUBMITTER: Rot U 

PROVIDER: S-EPMC6081760 | biostudies-literature | 2018 Jul-Sep

REPOSITORIES: biostudies-literature