Transcriptomic population markers for human population discrimination.

ABSTRACT:

Background

Numerous studies have demonstrated significant differences in the expression level across continental human populations. Most of published results were performed on B-cell lines materials examined under specific laboratory conditions, without further validation in a primary biological material. The goal of our study was to identify mRNA markers characterized by a significant and stable difference in the gene expression profile in Caucasian and Chinese populations, both in the commercially available B-lymphocyte cell lines and in the primary samples of the peripheral blood.

Results

The preliminary selection of population-differentiating transcripts was based on Illumina expression microarray analysis of the representative group of ethnically-specified B-lymphocyte

SUBMITTER: Daca-Roszak P 

PROVIDER: S-EPMC6081795 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature