Methods to discriminate primary from secondary dengue during acute symptomatic infection.

ABSTRACT:

Background

Dengue virus infection results in a broad spectrum of clinical outcomes, ranging from asymptomatic infection through to severe dengue. Although prior infection with another viral serotype, i.e. secondary dengue, is known to be an important factor influencing disease severity, current methods to determine primary versus secondary immune status during the acute illness do not consider the rapidly evolving immune response, and their accuracy has rarely been evaluated against an independent gold standard.

Methods

Two hundred and ninety-three confirmed dengue patients were classified as experiencing primary, secondary or indeterminate infections using plaque reduction neutralisation tests performed 6 months after resolution of the acute illness. We developed and valida

SUBMITTER: Nguyen THT 

PROVIDER: S-EPMC6081805 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature