Bioprospecting lovastatin production from a novel producer Cunninghamella blakesleeana.

ABSTRACT: Beside anti-cholesterol activity, lovastatin garners worldwide attention for therapeutical application against various diseases especially cancer. A total of 36 filamentous fungi from soil samples were isolated and screened for lovastatin production by yeast growth bioassay method. C9 strain (later identified as Cunninghamella blakesleeana) was screened as potential strain of lovastatin production. Further confirmation of the compound was made using TLC, HPTLC and HPLC in which similar Rf value, densitogram peak and chromatogram peak against the standard lovastatin were observed, respectively. The purified lovastatin subjected for IR analysis showed a lactone ring peak at 1763.63 cm^-1 similar to standard lovastatin. Further structural analysis including NMR and LC-MS of t

SUBMITTER: Balraj J 

PROVIDER: S-EPMC6081836 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature