Putative functional variants of lncRNA identified by RegulomeDB were associated with knee osteoarthritis susceptibility.

ABSTRACT:

Background

Knee osteoarthritis (KOA) is the most common form of chronic degenerative joint disease worldwide. Its incidence has increased in recent years. Aberrant expression profile of lncRNAs in damaged bone and cartilage of KOA patients has been reported recently, indicating its potential contributions in KOA development and a promising target for disease diagnosis and treatment. The aim of this study was to identify the association between genetic variation in lncRNA and KOA.

Methods

We retrieved relevant articles from the PubMed, Medline and Embase databases up to Jul 2017 investigating the association between lncRNA and the risk of osteoarthritis. There are 15 lncRNAs which show connection with osteoarthritis. We selected potential functional polymorphisms identified b

SUBMITTER: Wang K 

PROVIDER: S-EPMC6081910 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature