Comparative analysis of different dietary antioxidants on oxidative stress pathway genes in L6 myotubes under oxidative stress.

ABSTRACT: Enhanced oxidative stress plays an important role in the progression and onset of diabetes and its complications. Strategies or efforts meant to reduce the oxidative stress are needed which may mitigate these pathogenic processes. The present study aims to investigate the in vitro ameliorative potential of nine antioxidant molecules in L6 myotubes under oxidative stress condition induced by 4-hydroxy-2-nonenal and also to comprehend the gene expression patterns of oxidative stress genes upon the supplementation of different antioxidants in induced stress condition. The study results demonstrated a marked increase in the level of malondialdehyde and protein carbonyl content with a subsequent increase in the free radicals that was reversed by the pretreatment of different dietary antioxidant

SUBMITTER: Sarkar P 

PROVIDER: S-EPMC6081920 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature