Novel roles for scleraxis in regulating adult tenocyte function.

ABSTRACT:

Background

Tendinopathies are common and difficult to resolve due to the formation of scar tissue that reduces the mechanical integrity of the tissue, leading to frequent reinjury. Tenocytes respond to both excessive loading and unloading by producing pro-inflammatory mediators, suggesting that these cells are actively involved in the development of tendon degeneration. The transcription factor scleraxis (Scx) is required for the development of force-transmitting tendon during development and for mechanically stimulated tenogenesis of stem cells, but its function in adult tenocytes is less well-defined. The aim of this study was to further define the role of Scx in mediating the adult tenocyte mechanoresponse.

Results

Equine tenocytes exposed to siRNA targeting Scx or a cont

SUBMITTER: Nichols AEC 

PROVIDER: S-EPMC6081934 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature