Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits.

ABSTRACT: The alpha1 (α1) subunit of the sodium/potassium ATPase (i.e., Na⁺/K⁺-ATPase α1), the prototypical sodium pump, is expressed in each eukaryotic cell. They pump out three sodium ions in exchange for two extracellular potassium ions to establish a cellular electrochemical gradient important for firing of neuronal and cardiac action potentials. We hypothesized that myosin (myo or myh) motor proteins might interact with Na⁺/K⁺-ATPase α1 subunits in order for them to play an important role in the transport and trafficking of sodium pump. To this end immunoassays were performed to determine whether class II non-muscle myosins (i.e., NMHC-IIA/myh9, NMHC-IIB/myh10 or NMHC-IIC/myh14), myosin Va (myoVa) and myosin VI (myoVI) would interact with Na⁺

SUBMITTER: Dash B 

PROVIDER: S-EPMC6081954 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature