Ontology highlight
ABSTRACT:
SUBMITTER: Nicolle R
PROVIDER: S-EPMC6082139 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Cell reports 20171101 9
Preclinical models based on patient-derived xenografts have remarkable specificity in distinguishing transformed human tumor cells from non-transformed murine stromal cells computationally. We obtained 29 pancreatic ductal adenocarcinoma (PDAC) xenografts from either resectable or non-resectable patients (surgery and endoscopic ultrasound-guided fine-needle aspirate, respectively). Extensive multiomic profiling revealed two subtypes with distinct clinical outcomes. These subtypes uncovered speci ...[more]