The Misshapen kinase regulates the size and stability of the germline ring canals in the Drosophila egg chamber.

ABSTRACT: Intercellular bridges are conserved structures that allow neighboring cells to exchange cytoplasmic material; defects in intercellular bridges can lead to infertility in many organisms. Here, we use the Drosophila egg chamber to study the mechanisms that regulate intercellular bridges. Within the developing egg chamber, the germ cells (15 nurse cells and 1 oocyte) are connected to each other through intercellular bridges called ring canals, which expand over the course of oogenesis to support the transfer of materials from the nurse cells to the oocyte. The ring canals are enriched in actin and actin binding proteins, and many proteins have been identified that localize to the germline ring canals and control their expansion and stability. Here, we demonstrate a novel role for the Ste20 fa

SUBMITTER: Kline A 

PROVIDER: S-EPMC6082181 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature