Ultrastructural Morphology of the Optic Nerve Head in Aged and Glaucomatous Mice.

ABSTRACT:

Purpose

To study age- and intraocular pressure-induced changes in the glial lamina of the murine optic nerve on the ultrastructural level.

Methods

Naïve C57bl/6 mice at various ages spanning the time between early adulthood (3 months) and senescence (30 months) were used in this study. In addition, the intraocular pressure (IOP) was increased in a group of young mice by injection of microbeads into the anterior chamber. The unmyelinated segments of the optic nerve containing the glial lamina were prepared for transmission electron microscopy and imaged at high resolution.

Results

Axon packing density decreased slightly with age. Aging nerves contained higher numbers of enlarged and degenerating axons. Mean axonal diameter and in particular the variance of axonal diame

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC6082327 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature