Characterization of a NIR absorbing thienyl curcumin contrast agent for photoacoustic imaging.

ABSTRACT: The synthesis and characterization of a bis(2-dimethylaminothien-5-yl)curcumin boron difluoride chromophore is presented. Photophysical, electrochemical and computational investigations establish the properties of its absorption in the Vis-NIR spectral range relative to established curcumin dyes. Application of this thienyl curcumin dye as a photoacoustic contrast agent is investigated against the dicarbocyanine Cy5 dye in the 675-735 nm excitation range.

SUBMITTER: Bellinger S 

PROVIDER: S-EPMC6082415 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature