Randomised controlled feasibility trial of real versus sham repetitive transcranial magnetic stimulation treatment in adults with severe and enduring anorexia nervosa: the TIARA study.

ABSTRACT:

Objective

Treatment options for severe, enduring anorexia nervosa (SE-AN) are limited. Non-invasive neuromodulation is a promising emerging intervention. Our study is a feasibility randomised controlled trial of repetitive transcranial magnetic stimulation (rTMS) in individuals with SE-AN, which aims to inform the design of a future large-scale trial.

Design

Double-blind, parallel group, two-arm, sham-controlled trial.

Setting

Specialist eating disorders centre.

Participants

Community-dwelling people with anorexia nervosa, an illness duration of ≥3 years and at least one previous completed treatment.

Interventions

Participants received 20 sessions (administered over 4 weeks) of MRI-guided real or sham high-frequency rTMS to the left dorsolateral prefront

SUBMITTER: Dalton B 

PROVIDER: S-EPMC6082449 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature