Hepcidin as a potential predictor for preoperative anemia treatment with intravenous iron-A retrospective pilot study.

ABSTRACT: Preoperative anemia occurs in about one third of patients who undergo elective surgery and is associated with an impaired outcome. Therefore, screening of preoperative anemia was established in the context of a multidisciplinary Patient Blood Management (PBM) program at the University Hospital of Muenster, Germany. Anemic patients without contraindications were treated with intravenous (IV) iron (ferric carboxymaltose) to increase their hemoglobin (Hgb) levels and hence to treat anemia prior to surgery. Interestingly, we detected a large variability in the response of Hgb levels after IV iron administration. Systemic iron homeostasis is mainly regulated by the hepatic hormone hepcidin, which regulates the cell surface expression of the sole known iron exporter ferroportin. The objective of

SUBMITTER: Wittkamp C 

PROVIDER: S-EPMC6082514 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature