Evolution of HIV-1 within untreated individuals and at the population scale in Uganda.

ABSTRACT: HIV-1 undergoes multiple rounds of error-prone replication between transmission events, resulting in diverse viral populations within and among individuals. In addition, the virus experiences different selective pressures at multiple levels: during the course of infection, at transmission, and among individuals. Disentangling how these evolutionary forces shape the evolution of the virus at the population scale is important for understanding pathogenesis, how drug- and immune-escape variants are likely to spread in populations, and the development of preventive vaccines. To address this, we deep-sequenced two regions of the HIV-1 genome (p24 and gp41) from 34 longitudinally-sampled untreated individuals from Rakai District in Uganda, infected with subtypes A, D, and inter-subtype recombina

SUBMITTER: Raghwani J 

PROVIDER: S-EPMC6082572 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature