Relationships between estimated autozygosity and complex traits in the UK Biobank.

ABSTRACT: Inbreeding increases the risk of certain Mendelian disorders in humans but may also reduce fitness through its effects on complex traits and diseases. Such inbreeding depression is thought to occur due to increased homozygosity at causal variants that are recessive with respect to fitness. Until recently it has been difficult to amass large enough sample sizes to investigate the effects of inbreeding depression on complex traits using genome-wide single nucleotide polymorphism (SNP) data in population-based samples. Further, it is difficult to infer causation in analyses that relate degree of inbreeding to complex traits because confounding variables (e.g., education) may influence both the likelihood for parents to outbreed and offspring trait values. The present study used runs of homozy

SUBMITTER: Johnson EC 

PROVIDER: S-EPMC6082573 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature