Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits.

ABSTRACT:

Background

There has been considerable progress in identifying inflammatory bowel disease [IBD] susceptibility genes but little progress in examining the role of genetic variation in the development of the extra-intestinal manifestations [EIMs] of IBD. This study identified clinical, serological, and genetic factors associated with ocular EIMs [O-EIMs] in IBD.

Methods

We performed a retrospective case-control study of IBD patients, comparing those with and without O-EIMs using the Cedars-Sinai IBD Research Repository and the NIDDK IBD Genetics Consortium Repository. Genotyping was performed using Illumina whole genome platforms.

Results

In all, 124 cases and 3328 controls with available clinical data were identified; 103 cases and 2808 controls had genetic data availa

SUBMITTER: Taleban S 

PROVIDER: S-EPMC6082592 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature