The Carbohydrate-Insulin Model of Obesity: Beyond "Calories In, Calories Out".

ABSTRACT: Despite intensive research, the causes of the obesity epidemic remain incompletely understood and conventional calorie-restricted diets continue to lack long-term efficacy. According to the carbohydrate-insulin model (CIM) of obesity, recent increases in the consumption of processed, high-glycemic-load carbohydrates produce hormonal changes that promote calorie deposition in adipose tissue, exacerbate hunger, and lower energy expenditure. Basic and genetic research provides mechanistic evidence in support of the CIM. In animals, dietary composition has been clearly demonstrated to affect metabolism and body composition, independently of calorie intake, consistent with CIM predictions. Meta-analyses of behavioral trials report greater weight loss with reduced-glycemic load vs low-fat diets,

SUBMITTER: Ludwig DS 

PROVIDER: S-EPMC6082688 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature