Improved Visualization of Cortical Lesions in Multiple Sclerosis Using 7T MP2RAGE.

ABSTRACT: BACKGROUND AND PURPOSE:Cortical lesions are common and often extensive in multiple sclerosis but are difficult to visualize by MRI, leaving important questions about their clinical implications and response to therapy unanswered. Our aim was to determine whether cortical lesions are better visualized using magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) than T2*-weighted imaging on 7T MR imaging. MATERIALS AND METHODS:Brain MR imaging using T1-weighted MP2RAGE at 500-μm isotropic resolution, T2*-weighted gradient-echo, and T2*-weighted segmented echo-planar imaging sequences were collected for 13 patients with MS and 5 age-matched neurologically healthy controls on a 7T research system. One MS case underwent postmortem MR imaging including gradient-echo and MP2RAGE seq

SUBMITTER: Beck ES 

PROVIDER: S-EPMC6082739 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature