Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer.

ABSTRACT: Epigenetic modifications such as aberrant DNA methylation reshape the gene expression repertoire in cancer. Here, we used a clinically relevant hepatocellular carcinoma (HCC) mouse model (Alb-R26^Met) to explore the impact of DNA methylation on transcriptional switches associated with tumorigenesis. We identified a striking enrichment in genes simultaneously hypermethylated in CpG islands (CGIs) and overexpressed. These hypermethylated CGIs are located either in the 5'-UTR or in the gene body region. Remarkably, such CGI hypermethylation accompanied by gene upregulation also occurs in 56% of HCC patients, which belong to the "HCC proliferative-progenitor" subclass. Most of the genes upregulated and with hypermethylated CGIs in the Alb-R26^Met HCC model undergo the same

SUBMITTER: Arechederra M 

PROVIDER: S-EPMC6082886 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature