Textural features of cervical cancers on FDG-PET/CT associate with survival and local relapse in patients treated with definitive chemoradiotherapy.

ABSTRACT: We retrospectively reviewed the records of 142 patients with stage IB-IIIB cervical cancer who underwent ¹⁸F-FDG-PET/CT before external beam radiotherapy plus intracavitary brachytherapy and concurrent chemotherapy. The patients were divided into training and validation cohorts to confirm the reliability of predictors for recurrence. Kaplan-Meier analysis was performed and a Cox regression model was used to examine the effects of variables on overall survival (OS), progression-free survival (PFS), distant metastasis-free survival (DMFS), and pelvic relapse-free survival (PRFS). High gray-level run emphasis (HGRE) derived from gray-level run-length matrix most accurately and consistently predicted the presence of pelvic residual or recurrent tumors for both cohorts. In multivaria

SUBMITTER: Chen SW 

PROVIDER: S-EPMC6082904 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature