Aflatoxin B₁ residues in human livers and their relationship with markers of hepatic carcinogenesis in Sao Paulo, Brazil.

ABSTRACT: In this study, hepatic biopsies from autopsy cases in São Paulo, Brazil, showing hepatocellular carcinoma (HCC, n = 8), cirrhosis associated with viral hepatitis (VC, n = 20), cirrhosis associated with alcoholism (AC, n = 20), and normal livers (NL or controls, n = 10) were subjected to determination of aflatoxin B₁ (AFB₁) and its main metabolites, and of markers of hepatic carcinogenesis Only non-metabolized AFB₁ was detected in 13 samples (27.1%, N = 48) of liver disorders (HCC, VC and AC), at levels between 10.0 and 418.0 pg/g (mean: 76.6 ± 107.7 pg/g). Immuno-labeling of p53, cyclin D1, p21, β-catenin, and Prohibitin (PB) increased mainly in HCC patients, in relation to the controls. AFB₁+ samples of HCC pre

SUBMITTER: Ramalho LNZ 

PROVIDER: S-EPMC6082919 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature