Dynamical Analysis of the Regulatory Network Controlling Natural Killer Cells Differentiation.

ABSTRACT: Many disease fighting strategies have focused on the generation of NK cells, since they constitute the main immune barrier against cancer and intracellular pathogens such as viruses. Therefore, a predictive model for the development of NK cells would constitute a useful tool to test several hypotheses regarding the production of these cells during both physiological and pathological conditions. Here, we present a boolean network model that reproduces experimental results reported on the literature regarding the progressive stages of the development of NK cells in wild-type and mutant backgrounds. The model allows for the simulation of different conditions, including extracellular micro-environment as well as the simulation of genetic alterations. It also describes how NK cell differentiati

SUBMITTER: Liquitaya-Montiel AJ 

PROVIDER: S-EPMC6082967 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature