Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.

ABSTRACT:

Background & aims

Uncontrolled liver proliferation is a key characteristic of liver cancer; however, the mechanisms by which this occurs are not well understood. Elucidation of these mechanisms is necessary for the development of better therapy. The oncogene Gankyrin (Gank) is overexpressed in both hepatocellular carcinoma and hepatoblastoma. The aim of this work was to determine the role of Gank in liver proliferation and elucidate the mechanism by which Gank promotes liver proliferation.

Methods

We generated Gank liver-specific knock-out (GLKO) mice and examined liver biology and proliferation after surgical resection and liver injury.

Results

Global profiling of gene expression in GLKO mice showed significant changes in pathways involved in liver cancer and prolife

SUBMITTER: D'Souza AM 

PROVIDER: S-EPMC6083020 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature