Effect of genetic drift on determinants of protein evolution.

ABSTRACT: A number of previous studies reported that gene expression, tissue specificity, gene essentiality and the number of protein-protein interactions influence the rate of protein evolution. Here we investigated the influence of effective population size (Ne) on these determinants of protein evolution. For this purpose, we compared the ratio of non-synonymous-to-synonymous diversities (πN/πS) estimated for protein-coding genes of Mus musculus castaneus and Mus musculus musculus: populations with high and low Ne respectively. Our results revealed that the difference between πN/πS estimated for genes with high and low expression levels was significantly smaller for M. m. musculus compared to that observed for M. m. castaneus The difference between the πN/πS of broadly expressed and tissue specifi

SUBMITTER: Subramanian S 

PROVIDER: S-EPMC6083237 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature