Functional and structural connectivity of the amygdala underpins locus of control in mild cognitive impairment.

ABSTRACT: Locus of control (LOC) is an important personality trait. LOC over cognitive competency reflects an individual's perceived control of desired cognitive outcomes, which is critical for maintaining successful cognitive aging. It is important to understand the neural substrates of LOC over cognitive competency in older adults, especially for individuals at high risk of dementia. Here, we characterized a cohesive functional and structural connectivity profile underlying LOC among 55 older adults with amnestic mild cognitive impairment (aMCI), combining resting-state functional magnetic resonance imaging and diffusion tensor imaging. The results showed that both functional and structural connectivity between the medial prefrontal cortex and amygdala were significantly correlated with external L

SUBMITTER: Ren P 

PROVIDER: S-EPMC6083450 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature