DoGFinder: a software for the discovery and quantification of readthrough transcripts from RNA-seq.

ABSTRACT:

Background

Recent studies have described a widespread induction of transcriptional readthrough as a consequence of various stress conditions in mammalian cells. This novel phenomenon, initially identified from analysis of RNA-seq data, suggests intriguing new levels of gene expression regulation. However, the mechanism underlying naturally occurring transcriptional readthrough, as well as its regulatory consequences, still remain elusive. Furthermore, the readthrough response to stress has thus far not been investigated outside of mammalian species, and the occurrence of readthrough in many physiological and disease conditions remains to be explored.

Results

To facilitate a wider investigation into transcriptional readthrough, we created the DoGFinder software package, for t

SUBMITTER: Wiesel Y 

PROVIDER: S-EPMC6083495 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature