Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression.

ABSTRACT:

Background

Aging leads to decreased skeletal muscle function in mammals and is associated with a progressive loss of muscle mass, quality and strength. Age-related muscle loss (sarcopenia) is an important health problem associated with the aged population.

Results

We investigated the alteration of genome-wide transcription in mouse skeletal muscle tissue (rectus femoris muscle) during aging using a high-throughput sequencing technique. Analysis revealed significant transcriptional changes between skeletal muscles of mice at 3 (young group) and 24 (old group) months of age. Specifically, genes associated with energy metabolism, cell proliferation, muscle myosin isoforms, as well as immune functions were found to be altered. We observed several interesting gene expression chan

SUBMITTER: Lin IH 

PROVIDER: S-EPMC6083496 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature