Arc protein expression after unilateral intracranial self-stimulation of the medial forebrain bundle is upregulated in specific nuclei of memory-related areas.

ABSTRACT:

Background

Intracranial Self-Stimulation (ICSS) of the medial forebrain bundle (MFB) is a deep brain stimulation procedure, which has a powerful enhancement effect on explicit and implicit memory. However, the downstream synaptic plasticity events of MFB-ICSS in memory related areas have not been described thoroughly. This study complements previous work studying the effect of MFB-ICSS on the expression of the activity-regulated cytoskeleton-associated (Arc) protein, which has been widely established as a synaptic plasticity marker. We provide new integrated measurements from memory related regions and take possible regional hemispheric differences into consideration.

Results

Arc protein expression levels were analyzed 4.5 h after MFB-ICSS by immunohistochemistry in the hipp

SUBMITTER: Kadar E 

PROVIDER: S-EPMC6083502 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature