Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women.

ABSTRACT:

Background

Gestational diabetes (GDM) is a more common problem in India than in many other parts of the world but it is not known whether this is due to unique environmental factors or a unique genetic background. To address this question we examined whether the same genetic variants associated with GDM and Type 2 Diabetes (T2D) in Caucasians also were associated with GDM in North Indian women.

Methods

Five thousand one hundred pregnant women of gestational age 24-28 weeks from Punjab were studied by a 75 g oral glucose tolerance test (OGTT). GDM was diagnosed by both WHO1999 and 2013 criteria. 79 single nucleotide polymorphisms (SNPs) previously associated with T2D and glycemic traits (12 of them also with GDM) and 6 SNPs from previous T2D associations based on Indian popul

SUBMITTER: Arora GP 

PROVIDER: S-EPMC6083526 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature