Influence of Biological Therapeutics, Cytokines, and Disease Activity on Depression in Rheumatoid Arthritis.

ABSTRACT:

Purpose

Rheumatoid arthritis (RA) is an often debilitating autoinflammatory disease. Patients with rheumatoid arthritis are often troubled by co-occurring depression or other psychological manifestations. RA patients have a variety of treatment options available, including biologicals that inhibit cytokines or immune cells. If these cytokines influence the psychological symptoms, then the use of cytokine inhibitors should modulate these symptoms.

Methods

A cohort of 209 individuals was recruited. This group included 82 RA patients, 22 healthy subjects, 32 depressed control subjects, and 73 subjects with systemic lupus erythematosus. Of the RA patients, 51% were on a biological therapeutic. ELISA was used to measure cytokine levels. A variety of psychological assessments were

SUBMITTER: Figueiredo-Braga M 

PROVIDER: S-EPMC6083532 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature