Mammalian chromosome-telomere length dynamics.

ABSTRACT: Individual chromosome arms have specific individual telomere lengths (TLs). Past studies within species have shown strong positive correlations between individual chromosome length and TL at that chromosome. While the reasons for these associations are unclear, the strength and consistency of the associations across disparate taxa suggest that this is important to telomere biology and should be explored further. If TL is primarily determined by chromosome length, then chromosome length should be considered and controlled for in cross-species analyses of TL. Here, we employ a cross-species approach to explore whether the chromosome length-TL association observed intraspecifically is a determinant of mean TL across species. Data were compiled from two studies characterizing TL across a range

SUBMITTER: Klegarth AR 

PROVIDER: S-EPMC6083700 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature