Synthesis, characterization and biological application of 5-quinoline 1,3,5-trisubstituted pyrazole based platinum(ii) complexes.

ABSTRACT: Square planar mononuclear platinum(ii) complexes were synthesized in the presence of neutral bidentate heterocyclic (5-quinoline 1,3,5-tri-substituted pyrazole scaffold) ligands and K₂PtCl₄ salt. The synthesized compounds were characterized by micro-elemental analysis, FT-IR, UV-vis, ¹H NMR, ¹³C NMR, TGA, mass spectrometry and molar conductivity. Their biological activities were investigated by in vitro brine shrimp lethality bioassay, in vitro antimicrobial study against five different pathogens, in vivo cellular level cytotoxicity against Schizosaccharomyces pombe cells, and in vitro anti-proliferation assay. The binding constant K_sv, K_b, K_a values of the c

SUBMITTER: Lunagariya MV 

PROVIDER: S-EPMC6083784 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature