Pretreatment Rostral Anterior Cingulate Cortex Theta Activity in Relation to Symptom Improvement in Depression: A Randomized Clinical Trial.

ABSTRACT:

Importance

Major depressive disorder (MDD) remains challenging to treat. Although several clinical and demographic variables have been found to predict poor antidepressant response, these markers have not been robustly replicated to warrant implementation in clinical care. Increased pretreatment rostral anterior cingulate cortex (rACC) theta activity has been linked to better antidepressant outcomes. However, no prior study has evaluated whether this marker has incremental predictive validity over clinical and demographic measures.

Objective

To determine whether increased pretreatment rACC theta activity would predict symptom improvement regardless of randomization arm.

Design, setting, and participants

A multicenter randomized clinical trial enrolled outpatients with

SUBMITTER: Pizzagalli DA 

PROVIDER: S-EPMC6083825 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature