Racial differences in maternal and umbilical cord blood leukocyte telomere length and their correlations.

ABSTRACT:

Purpose

Telomere length at birth sets the baseline for telomere shortening and may influence adult disease risk like cancer. Telomere length is heritable, but may also be a marker of exposures in utero, including those influencing racial differences in risk. We examined racial differences in telomere length in maternal and umbilical cord blood from male neonates, and maternal-neonate correlations to generate hypotheses.

Methods

Black and white pregnant women were recruited in 2006-2007 and followed to postpartum. Data came from questionnaires and medical records. Relative telomere length was measured by qPCR in leukocyte DNA. We estimated mean telomere length in mothers and neonates (n = 55 pairs) using linear regression and maternal-cord blood Spearman correlations, overall

SUBMITTER: Weber KA 

PROVIDER: S-EPMC6083880 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature